Messenger RNA vaccines have issues.
[sic]
" If our hypothesis were to be confirmed, the implications for public health would be staggering and appalling in the context of the mass-scale COVID-19 vaccination already taking place, particularly if the
nms-mRNA enters brain
[82], bone marrow
[84], and – if already present in the vaccinee – cancerous or pre-cancerous cells
[143], or if the vaccine is administered to females early in their pregnancy and the
nms-mRNA transfects embryonic cells
[77]. It stands to reason that if our hypothesis is proven to be correct, any other mRNA vaccine candidate should be fully investigated to understand the cytoplasmic and nuclear sensor, intrinsic factors, and signalling pathways activated by every single and combined synthetic 5′ Cap, GC content, polyA tails, and UTRs modifications made to the vaccine mRNA in order to fully elucidate the extent of their downstream signalling mechanisms of action and the potential impacts on health. Knowledge gained from these studies will be crucial for understanding, beyond unproven assumptions, the safety of mRNA vaccines and mRNA-based therapies on human health. "
Therapeutic applications of synthetic mRNA were proposed more than 30 years ago, and are currently the basis of one of the vaccine platforms used at a massive scale as part of the public health strategy to get COVID-19 under control. To date, there ...
pmc.ncbi.nlm.nih.gov